Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC B7-H2/ICOSLG Human 10ug
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B7-H2/ICOSLG Protein Human (HEK293 His) is a polypeptide chain containing the C-termimal His tag produced in HEK293 cells ICOSLG is a number of the B7 family of co-stimulatory molecules
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Apexbio Technology LLC Nutlin-3a chiral 675576-98-4 200mg
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Nutlin-3a chiral (CAS 675576-98-4) is a small-molecule antagonist targeting mouse double minute 2 (MDM2) which functions as a negative regulator of the tumor suppressor TP53 By binding directly to the TP53-interacting pocket of MDM2 Nutlin-3a blocks the degradation of TP53 stabilizing the protein and activating TP53-dependent pathways Studies in solid tumors and lymphomas indicate that Nutlin-3a induces cell cycle arrest growth inhibition and apoptosis Research has demonstrated antitumor activity in vitro and in vivo highlighting its utility in studying TP53-related cell signaling pathways and its potential in cancer research applications
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Medchemexpress LLC Bromopride | 4093-35-0 | 99.5% | 200 MG
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Bromopride | 4093-35-0 | 99.5% | 200 MG
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Medchemexpress LLC Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG
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Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG
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Medchemexpress LLC Guanidinoethyl sulfo 25mg | 25MG
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Guanidinoethyl sulfo 25mg | 25MG
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TARGETMOL CHEMICALS INC TPEN 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. Purity 99.79%
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Apexbio Technology LLC Molnupiravir(Synonyms: EIDD-2801, MK-4482, Lagevrio, Molnupex, EIDD-1931-isopropyl ester, EIDD-2801 prodrug), 200mg, CAS: 2349386-89-4.
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Molnupiravir (CAS 2349386-89-4) is an orally bioavailable nucleoside analog prodrug metabolized intracellularly into an active nucleoside triphosphate derivative Its antiviral effect occurs once incorporated by viral RNA-dependent RNA polymerase into newly synthesized viral RNA inducing an accumulation of mutations that disrupt viral genome fidelity and replication In research applications Molnupiravir is extensively employed for in vitro and in vivo studies investigating antiviral activities replication mechanisms and pharmacological responses especially against RNA viruses such as SARS-CoV-2 influenza virus and other coronaviruses
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Apexbio Technology LLC MLN8237 (Alisertib) 1028486-01-2 200mg
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MLN8237 (Alisertib CAS 1028486-01-2) is an orally administered small molecule inhibitor targeting Aurora A kinase (AAK) an enzyme frequently overexpressed in various cancers and linked to tumor proliferation and progression Developed from its predecessor MLN8054 to reduce benzodiazepine-like side effects MLN8237 potently inhibits Aurora A kinase through reversible ATP-competitive binding (Ki 0 43 nmol/L) Given its demonstrated anti-tumor activity in preclinical in vitro and in vivo studies MLN8237 is currently under investigation for treating advanced malignancies
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Apexbio Technology LLC PF-2545920 1292799-56-4 200mg
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PF-2545920 is a small-molecule inhibitor targeting phosphodiesterase 10A (PDE10A) It is designed to selectively inhibit PDE10A thereby modulating neuronal cAMP and cGMP signaling within cortico-striato-thalamic circuits PF-2545920 exerts its biological activity primarily through selective inhibition of PDE10A In in vitro studies PF-2545920 demonstrates potent inhibitory activity with an IC50 value of 0 37 nM In experimental mouse models it increases striatal cGMP levels at doses around 1 mg/kg Based on these pharmacological properties PF-2545920 holds research potential in the investigation of PDE10A-associated neurobiology and neuropsychiatric conditions such as schizophrenia
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Cambridge Isotope Laboratories CGA 580 / 3L carbon steel cylinder packless brass angle ea
CGA 580 / 3L carbon steel cylinder packless brass angle ea
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Medchemexpress LLC Cisapride | 81098-60-4 | 99.9% | C23H29ClFNO4 | 200 MG
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Cisapride is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. It is also a hERG blocker with an IC50 value of 9.4 nM. This gastroprokinetic agent stimulates gastrointestinal motor activity and is intended for research use only.
- Orally active 5-HT4 receptor agonist
- hERG blocker
- Stimulates gastrointestinal motor activity
- Suitable for high-speed applications
- Available in various solid pack sizes
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Medchemexpress LLC Vebicorvir | 2090064-66-5 | 99.7% | 467.44 | 10 MM 1 ML
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Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. It suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s ranging from 1.84 μM to 7.3 μM. In vitro, it inhibits pgRNA, HBeAg, and HBsAg production, and is also an inhibitor of pgRNA encapsidation and rcDNA synthesis. The product appears as a white to off-white solid for research use only.
- Suppresses covalently closed circular DNA (cccDNA) formation
- Inhibits pgRNA, HBeAg, and HBsAg production
- Inhibits pgRNA encapsidation and rcDNA synthesis
- Appears as a white to off-white solid
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Ambeed 1Naphthoic acid
1-Naphthoic acid, 86-55-5, 98%
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TARGETMOL CHEMICALS INC Bucladesine sodium 200MG
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Also available in 2 g, 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-inflammatory activity. Purity 98.34%
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Medchemexpress LLC Olmutinib | 1353550-13-6 | 99.5% / 99.9% | 486.59 | 200 MG
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Olmutinib is an orally active and irreversible third-generation EGFR tyrosine kinase inhibitor. It binds to a cysteine residue near the kinase domain and is used for Non-Small Cell Lung Cancer (NSCLC). This product is for research use only.
- Orally active
- Irreversible third-generation EGFR tyrosine kinase inhibitor
- Binds to a cysteine residue near the kinase domain
- Used for Non-Small Cell Lung Cancer (NSCLC)
- For research use only
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